| Date | Day | Competition | Round | Opponent | Venue | Stadium | Attendance | Result | Score | Referee | Notes |
|---|
| 2025-07-19 | Saturday | F | 1 | Villefranche Beaujolais | N | Stade Gérard Houllier | 0 | W | 1 | 0 | Rémi Landry | |
| 2025-07-23 | Wednesday | F | 2 | RWD Molenbeek | N | Stade Gérard Houllier | 0 | D | 0 | 0 | | |
| 2025-07-26 | Saturday | F | 3 | Hamburger SV | A | Volksparkstadion | 45757 | W | 4 | 0 | Jarno Wienefeld | Two 60 minute halves |
| 2025-07-30 | Wednesday | F | 4 | Mallorca | N | Kufstein Arena | | W | 4 | 0 | Manuel Baumann | |
| 2025-08-02 | Saturday | F | 5 | Bayern Munich | A | Allianz Arena | 34500 | L | 1 | 2 | Florian Badstübner | |
| 2025-08-09 | Saturday | F | 6 | Getafe | N | Stade Pierre-Rajon | 5000 | W | 2 | 1 | Jérémie Pignard | |
| 2025-08-16 | Saturday | L1 | 1 | Lens | A | Stade Felix Bollaert-Delelis | 38137 | W | 1 | 0 | Romain Lissorgue | Debuts: Morton, Merah, Šulc and Karabec. |
| 2025-08-23 | Saturday | L1 | 2 | Metz | H | Groupama Stadium | 49853 | W | 3 | 0 | Eric Wattellier | Debuts: Kluivert, Moreira. |
| 2025-08-31 | Sunday | L1 | 3 | Marseille | H | Groupama Stadium | 52095 | W | 1 | 0 | François Letexier | |
| 2025-09-14 | Sunday | L1 | 4 | Rennes | A | Roazhon Park | 27392 | L | 1 | 3 | Ruddy Buquet | |
| 2025-09-19 | Friday | L1 | 5 | Angers | H | Groupama Stadium | 44437 | W | 1 | 0 | Clément Turpin | Debuts: Greif, Satriano, De Carvalho |
| 2025-09-25 | Thursday | EL | League Phase | Utrecht | A | Stadion Galgenwaard | 22083 | W | 1 | 0 | Horatiu Fesnic | |
| 2025-09-28 | Sunday | L1 | 6 | Lille | A | Stade Pierre-Mauroy | 45287 | W | 1 | 0 | Mathieu Vernice | |
| 2025-10-02 | Thursday | EL | League Phase | RB Salzburg | H | Groupama Stadium | 31767 | W | 2 | 0 | Andris Treimanis | |
| 2025-10-05 | Sunday | L1 | 7 | Toulouse | H | Groupama Stadium | 51414 | L | 1 | 2 | Thomas Léonard | |
| 2025-10-18 | Saturday | L1 | 8 | Nice | A | Allianz Riviera | 24122 | L | 2 | 3 | Jérôme Brisard | |
| 2025-10-23 | Thursday | EL | League Phase | FC Basel | H | Groupama Stadium | 35586 | W | 2 | 0 | Manfredas Lukjancukas | |
| 2025-10-26 | Sunday | L1 | 9 | Strasbourg | H | Groupama Stadium | 49058 | W | 2 | 1 | Eric Wattellier | |
| 2025-10-29 | Wednesday | L1 | 10 | Paris FC | A | Stade Jean-Bouin | 18445 | D | 3 | 3 | Jérémy Stinat | |
| 2025-11-02 | Sunday | L1 | 11 | Brest | A | Stade Francis-Le Blé | 14534 | D | 0 | 0 | Clément Turpin | |
| 2025-11-06 | Thursday | EL | League Phase | Real Betis | A | Estadio Benito Villamarín | 55836 | L | 0 | 2 | Matej Jug | |
| 2025-11-09 | Sunday | L1 | 12 | Paris Saint-Germain | H | Groupama Stadium | 58230 | L | 2 | 3 | Benoît Bastien | |
| 2025-11-23 | Sunday | L1 | 13 | Auxerre | A | Stade de l'Abbé-Deschamps | 17359 | D | 0 | 0 | Thomas Leonard | |
| 2025-11-27 | Thursday | EL | 5 | Maccabi Tel-Aviv | N | TSC Arena | 400 | W | 6 | 0 | Kristo Tohver | |
| 2025-11-30 | Sunday | L1 | 14 | Nantes | H | Groupama Stadium | 46449 | W | 3 | 0 | Abdelatif Kherradji | |
| 2025-12-07 | Sunday | L1 | 15 | Lorient | A | Stade du Moustoir | 16213 | L | 0 | 1 | Mathieu Vernice | |
| 2025-12-11 | Thursday | EL | 6 | Go Ahead Eagles | H | Groupama Stadium | 26403 | W | 2 | 1 | Juxhin Xhaja | |
| 2025-12-14 | Sunday | L1 | 16 | Le Havre | H | Groupama Stadium | 42168 | W | 1 | 0 | Marc Bollengier | |
| 2025-12-21 | Sunday | CDF | Round of 64 | Saint-Cyr-Collonges | H | Groupama Stadium | 28607 | W | 3 | 0 | Jérémie Pignard | |
| 2026-01-03 | Saturday | L1 | 17 | AS Monaco | A | Stade Louis II | 11828 | W | 3 | 1 | Jérôme Brisard | |
| 2026-01-11 | Sunday | CDF | Round of 32 | Lille | A | Stade Pierre-Mauroy | 20333 | W | 2 | 1 | Clément Turpin | Debut: Endrick |
| 2026-01-18 | Sunday | L1 | 18 | Brest | H | Groupama Stadium | 46046 | W | 2 | 1 | Romain Lissorgue | |
| 2026-01-22 | Thursday | EL | League Phase | BSC Young Boys | A | Stadion Wankdorf | 22746 | W | 1 | 0 | Aliyar Aghayev | |
| 2026-01-25 | Sunday | L1 | 19 | Metz | A | Stade Saint-Symphorien | 28000 | W | 5 | 2 | Eric Wattellier | |
| 2026-01-29 | Thursday | EL | League Phase | PAOK | H | Groupama Stadium | 26149 | W | 4 | 2 | Ricardo De Burgos Bengoetxea | |
| 2026-02-01 | Sunday | EL | 20 | Lille | H | Groupama Stadium | 56150 | W | 1 | 0 | François Letexier | |
| 2026-02-04 | Wednesday | CDF | Round of 16 | Laval | H | Groupama Stadium | 24678 | W | 2 | 0 | Ruddy Buquet | |
| 2026-02-07 | Saturday | L1 | 21 | Nantes | A | Stade de La Beaujoire | 30849 | W | 1 | 0 | Mathieu Vernice | |
| 2026-02-15 | Sunday | L1 | 22 | Nice | H | Groupama Stadium | 48618 | W | 2 | 0 | Thomas Leonard | |
| 2026-02-22 | Sunday | L1 | 23 | Strasbourg | A | Stade de La Meinau | 31137 | L | 1 | 3 | Ruddy Buquet | |
| 2026-03-01 | Sunday | L1 | 24 | Marseille | A | Stade Vélodrome | 66225 | L | 2 | 3 | Jérôme Brisard | |
| 2026-03-05 | Thursday | CDF | Quarter-Final | Lens | H | Groupama Stadium | 47879 | D | 2 | 2 | Benoît Bastien | OL lost 5-4 on pens. |
| 2026-03-08 | Sunday | L1 | 25 | Paris FC | H | Groupama Stadium | 42148 | D | 1 | 1 | Eric Wattellier | |
| 2026-03-12 | Thursday | EL | Round of 16 | Celta Vigo | A | Estadio de Balaídos | 21673 | D | 1 | 1 | Erik Lambrechts | |
| 2026-03-15 | Sunday | L1 | 26 | Le Havre | A | Stade Océane | 22264 | D | 0 | 0 | Jérémy Stinat | |
| 2026-03-19 | Thursday | EL | Round of 16 | Celta Vigo | H | Groupama Stadium | 41764 | L | 0 | 2 | Irfan Peljto | |
| 2026-03-22 | Sunday | L1 | 27 | AS Monaco | H | Groupama Stadium | 56039 | L | 1 | 2 | François Letexier | |
| 2026-04-05 | Sunday | L1 | 28 | Angers | A | Stade Raymond-Kopa | 14721 | D | 0 | 0 | Ruddy Buquet | |
| 2026-04-12 | Sunday | L1 | 29 | Lorient | H | Groupama Stadium | 43551 | W | 2 | 0 | Benoît Bastien | |
| 2026-04-19 | Sunday | L1 | 31 | Paris Saint-Germain | A | Parc des Princes | 47926 | W | 2 | 1 | Jérôme Brisard | |
| 2026-04-25 | Saturday | L1 | 31 | Auxerre | H | Groupama Stadium | 51440 | W | 3 | 2 | Ruddy Buquet | |
| 2026-05-03 | Sunday | L1 | 32 | Rennes | H | Groupama Stadium | 51460 | W | 4 | 2 | Clément Turpin | |
| 2026-05-10 | Sunday | L1 | 33 | Toulouse | A | Stadium de Toulouse | 26683 | L | 1 | 2 | Bastien Dechepy | |
| 2026-05-17 | Sunday | L1 | 34 | Lens | H | Groupama Stadium | 58227 | L | 0 | 4 | François Letexier | |
