| Date | Day | Competition | Round | Opponent | Venue | Stadium | Attendance | Result | Score | Referee | Notes |
|---|
| 2024-07-13 | Saturday | F | 1 | Chassieu-Décines | N | Stade Gérard Houllier | | W | 7 | 0 | | |
| 2024-07-19 | Friday | F | 2 | WSG Tirol | A | Gernot Langes Stadion | | W | 3 | 2 | | |
| 2024-07-24 | Wednesday | F | 3 | St Pauli | N | Silberstadt-Arena | 2500 | L | 0 | 1 | | |
| 2024-07-31 | Wednesday | F | 4 | Torino | N | Stade Pierre-Rajon | 7000 | D | 0 | 0 | | |
| 2024-08-03 | Saturday | F | 5 | Union Berlin | A | Stadion An Der Alten Försterei | 12317 | W | 4 | 0 | | |
| 2024-08-11 | Sunday | F | 6 | Arsenal | A | Emirates Stadium | 60000 | L | 0 | 2 | | |
| 2024-08-18 | Sunday | L1 | 1 | Rennes | A | Roazhon Park | 26026 | L | 0 | 3 | Benoît Millot | |
| 2024-08-24 | Saturday | L1 | 2 | AS Monaco | H | Groupama Stadium | 54392 | L | 0 | 2 | Stéphanie Frappart | |
| 2024-08-30 | Friday | L1 | 3 | Strasbourg | H | Groupama Stadium | 43805 | W | 4 | 3 | Thomas Leonard | |
| 2024-09-15 | Sunday | L1 | 4 | Lens | A | Stade Felix Bollaert-Delelis | 38116 | D | 0 | 0 | Bastien Dechepy | |
| 2024-09-22 | Sunday | L1 | 5 | Marseille | H | Groupama Stadium | 53228 | L | 2 | 3 | Benoît Bastien | |
| 2024-09-26 | Thursday | EL | League Phase | Olympiakos | H | Groupama Stadium | 24412 | W | 2 | 0 | Lawrence Visser | |
| 2024-09-29 | Sunday | L1 | 6 | Toulouse | A | Stadium de Toulouse | 30026 | W | 2 | 1 | Gaël Angoula | |
| 2024-10-03 | Thursday | EL | League Phase | Rangers | A | Ibrox Stadium | 41981 | W | 4 | 1 | Sven Jablonski | |
| 2024-10-06 | Sunday | L1 | 7 | Nantes | H | Groupama Stadium | 51888 | W | 2 | 0 | Marc Bollengier | |
| 2024-10-20 | Sunday | L1 | 8 | Le Havre | A | Stade Océane | 22490 | W | 4 | 0 | Abdelatif Kherradji | |
| 2024-10-24 | Thursday | EL | League Phase | Besiktas | H | Groupama Stadium | 27350 | L | 0 | 1 | Harm Osmers | |
| 2024-10-27 | Sunday | L1 | 9 | Auxerre | H | Groupama Stadium | 54868 | D | 2 | 2 | Jérémy Stinat | |
| 2024-11-01 | Friday | L1 | 10 | Lille | A | Stade Pierre-Mauroy | 45084 | D | 1 | 1 | Jérôme Brisard | |
| 2024-11-07 | Thursday | EL | League Phase | Hoffenheim | A | PreZero Arena | 18227 | D | 2 | 2 | Marian Alexandru Barbu | |
| 2024-11-10 | Sunday | L1 | 11 | Saint-Étienne | H | Groupama Stadium | 58082 | W | 1 | 0 | Willy Delajod | |
| 2024-11-23 | Saturday | L1 | 12 | Reims | A | Stade Auguste-Delaune | 18274 | D | 1 | 1 | Stéphanie Frappart | |
| 2024-11-28 | Thursday | EL | League Phase | Qarabağ | A | Tofiq Bahramov Republican Stadium | 25000 | W | 4 | 1 | Nenad Minakovic | Debut: Enzo Molebe |
| 2024-12-01 | Sunday | L1 | 13 | Nice | H | Groupama Stadium | 59977 | W | 4 | 1 | Bastien Dechepy | |
| 2024-12-07 | Saturday | L1 | 14 | Angers | A | Stade Raymond-Kopa | 16301 | W | 3 | 0 | Marc Bollengier | |
| 2024-12-12 | Thursday | EL | League Phase | Eintracht Frankfurt | H | Groupama Stadium | 41091 | W | 3 | 2 | Andris Treimanis | |
| 2024-12-15 | Sunday | L1 | 15 | Paris Saint-Germain | A | Parc des Princes | 47000 | L | 1 | 3 | Benoît Bastien | |
| 2024-12-21 | Saturday | CDF | Round of 64 | Feignies-Aulnoye | N | Stade du Hainaut | 12000 | W | 2 | 1 | Gaël Angoula | |
| 2025-01-04 | Saturday | L1 | 16 | Montpellier | H | Groupama Stadium | 48162 | W | 1 | 0 | Jérémy Stinat | |
| 2025-01-11 | Saturday | L1 | 17 | Brest | A | Stade Francis-Le Blé | 14735 | L | 1 | 2 | Eric Wattellier | |
| 2025-01-15 | Wednesday | CDF | Round of 32 | Bourgoin-Jallieu | A | Stade Pierre-Rajon | 6359 | D | 2 | 2 | Mikael Lesage | OL lost 4-2 on pens. |
| 2025-01-18 | Saturday | L1 | 18 | Toulouse | H | Groupama Stadium | 42750 | D | 0 | 0 | Benoît Millot | |
| 2025-01-23 | Thursday | EL | League Phase | Fenerbahçe | A | Şükrü Saracoğlu Stadium | 36722 | D | 0 | 0 | Simone Sozza | |
| 2025-01-26 | Sunday | L1 | 19 | Nantes | A | Stade de La Beaujoire | 32690 | D | 1 | 1 | Benoît Bastien | Last game in charge for Pierre Sage. |
| 2025-01-30 | Thursday | EL | League Phase | Ludogorets Razgrad | H | Groupama Stadium | 35448 | D | 1 | 1 | Anastasios Sidiropoulos | |
| 2025-02-02 | Sunday | L1 | 20 | Marseille | A | Stade Vélodrome | 66096 | L | 2 | 3 | Jérôme Brisard | First game in charge for Paulo Fonseca. |
| 2025-02-16 | Sunday | L1 | 22 | Montpellier | A | Stade de la Mosson | 16573 | W | 4 | 1 | Marc Bollengier | |
| 2025-02-23 | Sunday | L1 | 23 | Paris Saint-Germain | H | Groupama Stadium | 57777 | L | 2 | 3 | Eric Wattellier | |
| 2025-03-02 | Sunday | L1 | 24 | Brest | H | Groupama Stadium | 47804 | W | 2 | 1 | Benoît Millot | |
| 2025-03-06 | Thursday | EL | Round of 16 | FCSB | A | Arena Nationala | 53028 | W | 3 | 1 | Tobias Stieler | |
| 2025-03-09 | Sunday | L1 | 25 | Nice | A | Allianz Riviera | 23840 | W | 2 | 0 | Benoît Bastien | |
| 2025-03-13 | Thursday | EL | Round of 16 | FCSB | H | Groupama Stadium | 37322 | W | 4 | 0 | Anthony Taylor | |
| 2025-03-16 | Sunday | L1 | 26 | Le Havre | H | Groupama Stadium | 39991 | W | 4 | 2 | Bastien Dechepy | |
| 2025-03-28 | Friday | L1 | 27 | Strasbourg | A | Stade de La Meinau | 19496 | L | 2 | 4 | Romain Lissorgue | |
| 2025-04-05 | Saturday | L1 | 28 | Lille | H | Groupama Stadium | 53771 | W | 2 | 1 | Eric Wattellier | |
| 2025-04-10 | Thursday | EL | Quarter-Final | Manchester United | H | Groupama Stadium | 58018 | D | 2 | 2 | Glenn Nyberg | |
| 2025-04-13 | Sunday | L1 | 29 | Auxerre | A | Stade de l'Abbé-Deschamps | 17511 | W | 3 | 1 | Stéphanie Frappart | |
| 2025-04-17 | Thursday | EL | Quarter-Final | Manchester United | A | Old Trafford | 73228 | L | 4 | 5 | Sandro Scharer | (a.e.t) |
| 2025-04-20 | Sunday | L1 | 30 | Saint-Étienne | A | Stade Geoffroy-Guichard | 40372 | L | 1 | 2 | François Letexier | |
| 2025-04-26 | Saturday | L1 | 31 | Rennes | H | Groupama Stadium | 51034 | W | 4 | 1 | Marc Bollengier | |
| 2025-05-04 | Sunday | L1 | 32 | Lens | H | Groupama Stadium | 52020 | L | 1 | 2 | Jérémy Stinat | |
| 2025-05-10 | Saturday | L1 | 33 | AS Monaco | A | Stade Louis II | 13578 | L | 0 | 2 | Benoît Bastien | |
| 2025-05-17 | Saturday | L1 | 34 | Angers | H | Groupama Stadium | 56517 | W | 2 | 0 | Stéphanie Frappart | |
